منابع مشابه
Serological Markers of Cancer and Their Applications in Clinical Trials1
Strategies for the prevention of cancer include those aimed at reducing the incidence of cancer (primary prevention) and cancer mortality through early detection of tumors (secondary prevention). The efficacy of prevention interventions is evaluated by clinical trials. The conduct of clinical trials is aided by the use of serological indicators of the carcino genic process measured using plasma...
متن کاملComplications in Using Automated Methods to Increase Clinical Trial Accrual
Purpose: This paper reports on the issues involved in improving accruals for cancer-related clinical trials. Clinical trials aim to determine the efficacy of novel therapies and must be conducted before new medical treatments become available to the public. In order for the clinical trial to be successful, a predetermined number of patients with an appropriate set of medical conditions must be ...
متن کاملClinical Trial Accrual: Obstacles and Opportunities
Less than 2% of patients diagnosed with cancer participate in a clinical trial in the United States (1). Gynecologic oncology patients do not appear to participate in trials with any more frequently than other cancer types. While gains in progression free survival have continued to improve overall life span for women with advanced gynecologic cancers, more cures have not been realized. Clinical...
متن کاملPredicting accrual achievement: monitoring accrual milestones of NCI-CTEP-sponsored clinical trials.
PURPOSE The need to increase the number oncology clinical trials with sufficient enrollments is a well-known issue, particularly for trials targeting therapeutic applications. It is critical to identify early predictors of eventual study accrual achievement. EXPERIMENTAL DESIGN All nonpediatric phase I, I/II, II, and III therapeutic studies supported by the National Cancer Institute Cancer Th...
متن کاملInter-temporal Accrual Persistence and Accrual Anomaly
Prior accounting research argues that diminishing marginal returns on new investments drive lower persistence of accruals relative to cash flows. Macroeconomic research documents that marginal profitability is counter-cyclical, which implies that diminishing marginal returns on new investments are more pronounced during periods of expansions than recessions. Linking the cyclicality of diminishi...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1988
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/80.12.884